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KMID : 0360319950270020353
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 2 p.353 ~ p.359
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A Study on Concentration of Carotenoids and a-Tocopherol in Mucosa of the Gastric Cancer Patients
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이윤경
염경진/이경식/박인서/송시영/이양자
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Abstract
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To explore the relationships between carotenoids, a-tocopherol and gastric cancer we determined the concentration of β-carotene, lycopene, and a-tocopherol in mucosa from gastric cancer patients and control subjects with mild gastritis.
The concentrations of β-carotene in both cancerous and non-cancerous gastric mucosa from cancer patients(242.5ng/g, 197.6ng/g) were significantly lower than those of control subjects(355.0ng/g). Lycopene concentrations in both cancerous and
non-cancerous gastric mucosa from cancer patients(92.8ng/g, 64.3ng/g) were also significantly lower than those of control(162.6ng/g). The a-to-copherol concentrations of cancerous(12.4μg/g) and non-cancerous mucosa(16.9μg/g) were lower than
those
of
control(18.5μg/g)but, the difference was not significant
Carotenoids and a-tocopherol were almost equally distributes in gastric mucosa. The concentrations of β-carotene, lycopene, and a-tocopherol in gastric mucosa of females were higher than those of males for both cancer and control groups. The
concentration of β-carotene decreased gradually with advancing age. Thus, β-carotene and lycopene might be protective against gastric cancer.
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KEYWORD
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B-bcarotene, Lycopene, a-tocopherol, Gastric cancer
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